Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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FTO (Q9C0B1) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4CXX_A 100 0 2.71Å 640 2014-10-01
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 5ZMD_G 100 0 3.3Å OGA 2019-04-10
FTO catalytic domain (46%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 6AEJ_A 100 0 2.79Å 7YC 2019-06-19
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4IE4_A 100 0 2.5Å 8XQ 2013-04-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 5ZMD_E 100 0 3.3Å OGA 2019-04-10
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4IE0_A 100 0 2.53Å PD2 2013-04-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4IE6_A 100 0 2.5Å UN9 2013-04-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4IDZ_A 100 0 2.46Å OGA 2013-04-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4ZS3_A 100 0 2.45Å A4F AKG 2015-11-04
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4QKN_A 100 0 2.05Å OGA JMS 2014-12-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 6AKW_A 100 0 2.2Å AKG 8S3 2019-05-29
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 3LFM_A 100 0 2.49Å OGA 3DT 2010-04-07
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4IE7_A 100 0 2.6Å RHN 2013-04-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 5DAB_A 100 0 2.1Å AKG 58W 2016-08-24
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 5F8P_A 100 0 2.199Å AKG FIJ 2016-12-14
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 5ZMD_A 100 0 3.3Å OGA 2019-04-10
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4ZS2_A 100 0 2.15Å AKG FLU 2015-11-04
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 5ZMD_C 100 0 3.3Å OGA 2019-04-10
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4QHO_A 100 0 2.32Å NKG 2015-06-03
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4IE5_A 100 0 1.95Å MD6 2013-04-03
FTO catalytic domain (46%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 6AK4_A 100 0 2.8Å PD9 2019-07-10
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4CXY_A 100 0 2.6Å DGR 2014-10-01
FTO catalytic domain (100%), FTO C-terminal domain (100%) (view alignment) FTO (Q9C0B1) - HUMAN 4CXW_A 100 0 3.05Å 6MK 2014-10-01