Molecular Target Synopsis
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FTO (Q9C0B1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed23
Chains with at least one site assessed as druggable using the strict criteria22
Chains with at least one site assessed as druggable using the relaxed criteria23


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4CXX_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 73 42.9 Yes Yes
2 empty 2.21 66.1 26.9 No No
3 empty 2.37 64.9 30.1 No No
4 empty 2.14 64.6 42.7 No No
5 empty 2.58 59.7 34.9 No No
6 empty 1.88 67.4 23.5 No No
7 empty 2.09 65.3 23.6 No No
8 empty 1.77 68.1 14.1 No No
9 empty 2.42 64.7 12.9 No No
10 empty 2.7 74 13.6 No No
5ZMD_G Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 70.3 47.4 Yes Yes
2 empty 2.16 62.1 23.3 No No
3 empty 2.15 62.1 36.2 No No
4 empty 2.55 66.5 23.3 No No
5 empty 1.39 67.8 18.2 No No
6 empty 2.47 63.3 16.2 No No
7 empty 2.61 76.7 20.3 No No
8 empty 2.29 68.3 17.1 No No
9 empty 2.86 66.9 19.7 No No
10 empty 1.8 62.4 16.3 No No
6AEJ_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 71.3 43.6 Yes Yes
2 empty 2.32 67.6 28.3 No No
3 empty 2.12 64.1 33.2 No No
4 empty 2.21 64.2 20 No No
5 empty 2.2 67.8 20.1 No No
6 empty 2.11 61.6 24 No No
7 empty 2.25 68.9 19 No No
8 empty 2.3 68 18.6 No No
9 empty 1.83 62.7 23.8 No No
10 empty 1.88 60.3 14.8 No No
4IE4_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 69.5 41 Yes Yes
2 empty 2.21 63.8 41.8 No No
3 empty 2.43 66.3 41.6 No No
4 empty 2.15 65.6 22.7 No No
5 empty 2.35 64.8 18.8 No No
6 empty 1.89 60.5 24.9 No No
7 empty 2.09 67 16.1 No No
8 empty 2.14 60.2 18 No No
9 empty 2.29 73.6 10.4 No No
10 empty 1.82 63.2 15.7 No No
5ZMD_E Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 73.8 29.7 Yes Yes
2 empty 2.38 64.6 36.5 No No
3 empty 1.89 62.9 37.1 No No
4 empty 1.49 67.6 17.2 No No
5 empty 2.3 61.7 22.1 No No
6 empty 2.44 65.4 25.8 No No
7 empty 2.42 67.8 20.8 No No
8 empty 2.4 62.8 14.6 No No
9 empty 2.05 65.1 21.2 No No
10 empty 2.22 62.4 17.3 No No
4IE0_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 67.4 40 Yes Yes
2 empty 2.2 62.7 45.8 No No
3 empty 2.08 65.8 33 No No
4 empty 2.1 67.6 23.8 No No
5 empty 2.3 66.5 16.7 No No
6 empty 2.28 65.2 19.9 No No
7 empty 1.75 60.6 23.9 No No
8 empty 2.36 66.3 20 No No
9 empty 1.75 73.9 14.2 No No
10 empty 2.42 64.2 21.3 No No
4IE6_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 60.2 51.6 Yes No
2 bound 1.58 69.9 41.7 No No
3 empty 2.29 63.7 40.3 No No
4 empty 2.09 67.7 22.1 No No
5 empty 1.87 59.4 23.6 No No
6 empty 2.04 73.2 15.5 No No
7 empty 2.22 65.1 19.9 No No
8 empty 2.24 81.4 11.9 No No
9 empty 2.41 71.2 12.4 No No
10 empty 2.27 78.6 10.6 No No
4IDZ_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 67.8 42.1 Yes Yes
2 empty 2.07 65.2 29.4 No No
3 empty 2.48 67.8 21 No No
4 empty 2.1 67.1 23.6 No No
5 empty 2.33 65.6 22.4 No No
6 empty 2.28 64.4 21 No No
7 empty 2.23 66 19.1 No No
8 empty 1.74 58.9 22.8 No No
9 empty 2.02 67.6 19.2 No No
10 empty 2.27 62.8 17.6 No No
4ZS3_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.46 72.5 41.3 Yes Yes
2 empty 2.05 70.2 30.9 No No
3 empty 2.5 66.5 28.5 No No
4 empty 2.3 69.8 25.9 No No
5 empty 2.34 64 28.7 No No
6 empty 2.4 62.2 28.1 No No
7 empty 2.59 66.1 18.3 No No
8 empty 1.84 59.8 24.1 No No
9 empty 2.09 60.1 14.4 No No
10 empty 2.33 58.4 14 No No
4QKN_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 66.6 43.2 Yes Yes
2 empty 2.37 67.7 35 No No
3 empty 2 68.7 31.6 No No
4 empty 2.54 65.8 18.6 No No
5 empty 2.39 63.6 22.7 No No
6 empty 1.96 70 19.9 No No
7 empty 2.18 56.8 27.6 No No
8 empty 2.37 69.8 21 No No
9 empty 2.33 65.1 20.1 No No
10 empty 2.19 62.3 12.8 No No
6AKW_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 70.9 33.3 Yes Yes
2 empty 1.93 66.4 30.8 No No
3 empty 2.51 70.4 26.1 No No
4 empty 2.34 62.5 17.5 No No
5 empty 1.9 68.4 18.6 No No
6 empty 2.23 61.7 30.4 No No
7 empty 1.92 68 20.7 No No
8 empty 1.79 63 24.3 No No
9 empty 2.32 64.3 18 No No
10 empty 1.94 64.2 18 No No
3LFM_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 71.6 42.5 Yes Yes
2 empty 2.1 64.3 31.4 No No
3 empty 2.37 65.4 23.9 No No
4 empty 1.92 63.7 26.9 No No
5 empty 2.65 70.9 23.1 No No
6 empty 2.47 66.2 20.8 No No
7 empty 2.12 62.4 19.8 No No
8 empty 1.89 59.4 27.1 No No
9 empty 2.19 68.6 21.5 No No
10 empty 2.24 68 18.3 No No
4IE7_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 69.9 43.2 Yes Yes
2 empty 2.32 62.2 45 No No
3 empty 2.23 64.8 32.8 No No
4 empty 2.09 66.3 26.2 No No
5 empty 2.05 62.9 23 No No
6 empty 1.82 58 23.2 No No
7 empty 2 67.8 19.1 No No
8 empty 2 77.4 13 No No
9 empty 1.94 64.1 12 No No
10 empty 2.13 63.8 11.4 No No
5DAB_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 67.6 45.2 Yes Yes
2 empty 2.47 65.5 36.3 No No
3 empty 2.34 62.3 30 No No
4 empty 2.11 66.6 22.7 No No
5 empty 1.98 68.5 26.2 No No
6 empty 2.24 72.1 19.8 No No
7 empty 2.27 65.1 24 No No
8 empty 1.96 67.3 16 No No
9 empty 1.9 60.9 24 No No
10 empty 2.29 59.5 19.5 No No
5F8P_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 66.5 44.1 Yes Yes
2 empty 2.63 67 26.2 No No
3 empty 2.26 64.1 30.6 No No
4 empty 2.06 67.4 29.7 No No
5 empty 2.17 62.5 29.9 No No
6 empty 2.22 59.1 18.5 No No
7 empty 2.36 72.9 19.7 No No
8 empty 1.88 57.4 16.9 No No
9 empty 1.92 61.9 23.2 No No
10 empty 2.43 61.4 11.9 No No
5ZMD_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 70.6 45.4 Yes Yes
2 empty 1.88 67.2 37.6 No No
3 empty 2.54 65.8 30.8 No No
4 empty 2.09 61.4 39.1 No No
5 empty 2.58 62 20.8 No No
6 empty 2.18 66.6 24.9 No No
7 empty 2.39 66.3 27.6 No No
8 empty 2.7 78.3 12 No No
9 empty 2.43 69.6 15.2 No No
10 empty 2.46 72.7 13.4 No No
4ZS2_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 70.3 42 Yes Yes
2 empty 2.38 66.5 37.4 No No
3 empty 2.17 74.2 29 No No
4 empty 2.08 69.3 30.9 No No
5 empty 2.56 68.2 17.5 No No
6 empty 2.61 64.4 22.3 No No
7 empty 1.9 65.1 19.5 No No
8 empty 2.31 54.8 15.4 No No
9 empty 1.84 61.7 24 No No
10 empty 2.21 66.9 20.1 No No
5ZMD_C Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.48 72.9 29.2 Yes Yes
2 empty 2.31 62.5 35.9 No No
3 empty 2.39 69 31.3 No No
4 empty 1.73 66.7 22.8 No No
5 empty 2.41 65.1 17.9 No No
6 empty 2.14 61.9 33.8 No No
7 empty 2.21 65.7 21.8 No No
8 empty 2.36 60.5 25.6 No No
9 empty 2.1 67.8 17.8 No No
10 empty 2.2 72.7 18.7 No No
4QHO_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 68.6 43.7 Yes Yes
2 empty 2.46 65.5 46.4 No No
3 empty 2.4 63.3 46.5 No No
4 empty 2.04 62.6 23 No No
5 empty 2.12 64.6 22.4 No No
6 empty 1.85 60.5 21.9 No No
7 empty 1.95 68.4 19 No No
8 empty 2.34 74 10 No No
9 empty 2.29 53.2 12.5 No No
10 empty 2.11 66.7 16.7 No No
4IE5_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 67.8 44.3 Yes Yes
2 empty 2.23 66.2 25.1 No No
3 empty 2.32 66.1 26.3 No No
4 bound 1.97 64.4 28.9 No No
5 empty 2.27 61.3 35.7 No No
6 empty 2.33 61.7 18.4 No No
7 empty 2.29 62.9 21.3 No No
8 empty 2.11 59.5 25.1 No No
9 empty 1.99 65.5 19.6 No No
10 empty 2.25 68.9 15.8 No No
6AK4_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 72.2 43.8 Yes Yes
2 empty 2.02 63.4 30.7 No No
3 empty 2.42 69.3 27.4 No No
4 empty 2.13 62.3 27.3 No No
5 empty 1.86 61.6 25 No No
6 empty 2.32 60.1 21.5 No No
7 empty 2.18 62.2 20.8 No No
8 empty 2.28 69.6 19.2 No No
9 empty 2.26 65.7 18.1 No No
10 empty 2.32 63.8 16.8 No No
4CXY_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 73.3 38.9 Yes Yes
2 empty 2.28 66.1 52.3 No No
3 empty 2.32 61.1 28.4 No No
4 empty 2.23 71.8 22.4 No No
5 empty 2.01 68.9 29.3 No No
6 empty 2.05 58 26.6 No No
7 empty 2.32 64.9 19.8 No No
8 empty 2.16 69.7 17.3 No No
9 empty 2.01 51.3 10.9 No No
10 empty 2.25 70.5 11.8 No No
4CXW_A Alpha-ketoglutarate-dependent dioxygenase FTO Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 70.8 48.3 Yes Yes
2 empty 2.47 66.9 44.4 No No
3 empty 2.45 52.9 23.7 No No
4 empty 2.32 63 21.3 No No
5 empty 2.05 71.7 29.4 No No
6 empty 1.82 57.1 23.5 No No
7 empty 1.89 65.2 19.6 No No
8 empty 2 64 14.1 No No
9 empty 2.46 51.7 18.4 No No
10 empty 1.95 73.7 9.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3LFM_A (3530165) Alpha-ketoglutarate-dependent dioxygenase FTO P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, ABC transporter ATPase domain-like 2.49Å Yes No
3LFM_A (3530164) Alpha-ketoglutarate-dependent dioxygenase FTO IF3-like, SirA-like, SirA-like 2.49Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score