Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DCLK3 (Q9C098) - Overview - Molecular Target Synopsis

Protein


DCLK3, Serine/threonine-protein kinase DCLK3
Enzyme Classification 2.7.11.1
UniProt Q9C098

Also Known as DCLK3_HUMAN, DCLK3, DCAMKL3, DCDC3C, KIAA1765

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
648ENSG00000163673ENST00000416516ENSP00000394484Q9C098-1

Sub-cellular localization


UniProt: DCLK3 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: DCLK3 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DCLK3 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, HS578T, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC33, CPC-N, NCI-H2106

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


DCLK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB134VI, COV504. (see details)

3D Structures


At greater than 50% identity similarity to DCLK3 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DCLK3 has been screened with 97 compounds (138 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)