Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB34 (Q9BZG1) - Overview - Molecular Target Synopsis

Protein


RAB34, Ras-related protein Rab-34
UniProt Q9BZG1

Also Known as RAB34_HUMAN, RAB34, RAB39, RAH

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. Interacts with RILP.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB34 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, cytoplasmic vesicle, golgi apparatus, phagosome, phagosome membrane.
GO terms: RAB34 is active in the following subcellular-locations: cilium, extracellular exosome, Golgi apparatus, Golgi cisterna, Golgi stack, perinuclear region of cytoplasm, phagocytic vesicle, phagocytic vesicle membrane, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB34 has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, NCI_H460, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, OVISE, G28T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, IMR-90

(see details)

3D Structures


At greater than 35% identity similarity to RAB34 there are:
92 structures (174 chains) solved
83 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB34 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB34 has been screened with compounds ( bioactivities). (see details)