Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB34 (Q9BZG1) - Overview - Molecular Target Synopsis


RAB34, Ras-related protein Rab-34
UniProt Q9BZG1

Also Known as RAB34_HUMAN, RAB34, RAB39, RAH

Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. Interacts with RILP.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAB34 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, cytoplasmic vesicle, golgi apparatus, phagosome, phagosome membrane.
GO terms: RAB34 is active in the following subcellular-locations: cilium, extracellular exosome, Golgi apparatus, Golgi cisterna, Golgi stack, perinuclear region of cytoplasm, phagocytic vesicle, phagocytic vesicle membrane, vesicle.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB34 has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A549, NCI_H460, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, OVISE, G28T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, IMR-90

(see details)

3D Structures

At greater than 35% identity similarity to RAB34 there are:
92 structures (174 chains) solved
83 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB34 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB34 has been screened with compounds ( bioactivities). (see details)