Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA2 (Q9BZC7) - Overview - Molecular Target Synopsis

Protein


ABCA2, ATP-binding cassette sub-family A member 2
UniProt Q9BZC7

Also Known as ABCA2_HUMAN, ABCA2, ABC2, KIAA1062

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA2 is active in the following subcellular-locations: endosome membrane, lysosome membrane.
GO terms: ABCA2 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, cytoplasmic vesicle, endosome, endosome membrane, integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, lysosome, membrane, microtubule organizing center.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SNB_75, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, KG-1, HNT-34

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)

3D Structures


At greater than 35% identity similarity to ABCA2 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA2 has been screened with compounds ( bioactivities). (see details)