Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABCA2 (Q9BZC7) - Overview - Molecular Target Synopsis


ABCA2, ATP-binding cassette sub-family A member 2
UniProt Q9BZC7

Also Known as ABCA2_HUMAN, ABCA2, ABC2, KIAA1062

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ABCA2 is active in the following subcellular-locations: endosome membrane, lysosome membrane.
GO terms: ABCA2 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, cytoplasmic vesicle, endosome, endosome membrane, integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, lysosome, membrane, microtubule organizing center.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABCA2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: T47D, SNB_75, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, KG-1, HNT-34

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)

3D Structures

At greater than 35% identity similarity to ABCA2 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ABCA2 has been screened with compounds ( bioactivities). (see details)