Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOBTB2 (Q9BYZ6) - Overview - Molecular Target Synopsis

Protein


RHOBTB2, Rho-related BTB domain-containing protein 2
UniProt Q9BYZ6

Also Known as RHBT2_HUMAN, RHOBTB2, DBC2, KIAA0717

Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842). Interacts with CUL3 (PubMed:29276004).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RHOBTB2 is active in the following subcellular-locations: cytoplasm, cytosol, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOBTB2 has gain in 0 cell-lines, loss in 12 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, MDA_MB_435, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, RPMI 2650, NCI-H1568

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HMEC, A549

(see details)

3D Structures


At greater than 35% identity similarity to RHOBTB2 there are:
144 structures (241 chains) solved
113 are solved in complex with at least one small molecule ligand
5 are solved with an approved drug

RHOBTB2 is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (2WKP_A, 2WKQ_A, 2WKR_A, 5HZH_A),
AMP/ADENOSINE PHOSPHATE (4ITR_C, 4ITR_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOBTB2 has been screened with compounds ( bioactivities). (see details)