Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

POTEKP (Q9BYX7) - Overview - Molecular Target Synopsis

Protein


POTEKP, Putative beta-actin-like protein 3
UniProt Q9BYX7

Also Known as ACTBM_HUMAN, POTEKP, ACTBL3

Interacts with PFN1 and PFDN1. Does not interact with PFN2.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
375Q9BYX7-1

Sub-cellular localization


UniProt: POTEKP is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: POTEKP is active in the following subcellular-locations: cytoskeleton, cytosol, extracellular exosome, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project POTEKP has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CPC-N, NCI-H847, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, GM12878, SK-N-SH

(see details)

3D Structures


At greater than 90% identity similarity to POTEKP there are:
21 structures (69 chains) solved
11 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


POTEKP has been screened with compounds ( bioactivities). (see details)