Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK33 (Q9BYT3) - Overview - Molecular Target Synopsis


STK33, Serine/threonine-protein kinase 33
Enzyme Classification
UniProt Q9BYT3

Also Known as STK33_HUMAN, STK33

Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines. Interacts with VIME.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: STK33 is active in the following subcellular-locations: cytoplasm, perinuclear region.
GO terms: STK33 is active in the following subcellular-locations: cytoplasm, nucleus, perinuclear region of cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK33 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HOP_62, U251, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2196, HM7, A-375

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

RNA Interference

STK33 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PCI30, PL5. (see details)

3D Structures

At greater than 35% identity similarity to STK33 there are:
109 structures (155 chains) solved
88 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

STK33 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK33 has been screened with 344 compounds (568 bioactivities), 27 compounds have bioactivities that show binding affinity of <= 500nM (32 bioactivities). (see details)