Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTRT3 (Q9BYD9) - Overview - Molecular Target Synopsis

Protein


ACTRT3, Actin-related protein T3
UniProt Q9BYD9

Also Known as ACTT3_HUMAN, ACTRT3, ARPM1

Interacts with PFN3.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
372ENSG00000184378ENST00000330368ENSP00000333037Q9BYD9-1

Sub-cellular localization


UniProt: ACTRT3 is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleus.
GO terms: ACTRT3 is active in the following subcellular-locations: cytoplasm, cytoskeleton, male germ cell nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTRT3 has gain in 20 cell-lines, loss in 0 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, COV434, SK-OV-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to ACTRT3 there are:
4 structures (21 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTRT3 has been screened with compounds ( bioactivities). (see details)