Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC46A2 (Q9BY10) - Overview - Molecular Target Synopsis

Protein


SLC46A2, Thymic stromal cotransporter homolog
UniProt Q9BY10

Also Known as TSCOT_HUMAN, SLC46A2, TSCOT

May act as a transporter.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
475ENSG00000119457ENST00000374228ENSP00000363345Q9BY10-1
341ENSG00000119457ENST00000491462ENSP00000474847

Sub-cellular localization


UniProt: SLC46A2 is active in the following subcellular-locations: cell membrane.
GO terms: SLC46A2 is active in the following subcellular-locations: cell surface, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC46A2 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, ACHN, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, SK-N-SH, NHLF

(see details)