Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK31 (Q9BXU1) - Overview - Molecular Target Synopsis

Protein


STK31, Serine/threonine-protein kinase 31
Enzyme Classification 2.7.11.1
UniProt Q9BXU1

Also Known as STK31_HUMAN, STK31, SGK396

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: STK31 is active in the following subcellular-locations: acrosomal vesicle, cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK31 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, KM12, DU_145

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-484, KMM-1, C2BBe1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


STK31 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: 93VU, H23. (see details)


Screening and Chemistry


STK31 has been screened with 1 compounds (1 bioactivities). (see details)