PINK1 (Q9BXM7) - Overview - Molecular Target Synopsis
PINK1, Serine/threonine-protein kinase PINK1, mitochondrial
Enzyme Classification 184.108.40.206
Also Known as PINK1_HUMAN, PINK1
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10. Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7 (PubMed:19229105).
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UniProt: PINK1 is active in the following subcellular-locations: cytoplasm, cytosol, mitochondrion inner membrane, mitochondrion outer membrane.
GO terms: PINK1 is active in the following subcellular-locations: astrocyte projection, axon, cell body, chromatin, cytoplasm, cytoskeleton, cytosol, growth cone, integral component of mitochondrial outer membrane, Lewy body, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial outer membrane, mitochondrion, nucleus, perinuclear region of cytoplasm.