Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TSSK1B (Q9BXA7) - Overview - Molecular Target Synopsis

Protein


TSSK1B, Testis-specific serine/threonine-protein kinase 1
Enzyme Classification 2.7.11.1
UniProt Q9BXA7

Also Known as TSSK1_HUMAN, TSSK1B, SPOGA1, SPOGA4, STK22A, STK22D, TSSK1

Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Interacts with TSSK2. Interacts with HSP90; this interaction stabilizes TSSK1 (By similarity).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
430ENSG00000212122ENST00000390666ENSP00000375081
367Q9BXA7-1

Sub-cellular localization


UniProt: TSSK1B is active in the following subcellular-locations: acrosome, cell projection, cilium, cytoplasm, cytoplasmic vesicle, flagellum, secretory vesicle.
GO terms: TSSK1B is active in the following subcellular-locations: acrosomal vesicle, cytoplasm, motile cilium, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TSSK1B has gain in 0 cell-lines, loss in 5 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, RPMI_8226, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


TSSK1B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MG63, G292. (see details)

3D Structures


At greater than 35% identity similarity to TSSK1B there are:
89 structures (156 chains) solved
62 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TSSK1B is solved in complex with the approved drug(s):

XIN/NINTEDANIB (5MAF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TSSK1B has been screened with 721 compounds (1317 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)