Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TSSK6 (Q9BXA6) - Overview - Molecular Target Synopsis

Protein


TSSK6, Testis-specific serine/threonine-protein kinase 6
Enzyme Classification 2.7.11.1
UniProt Q9BXA6

Also Known as TSSK6_HUMAN, TSSK6, SSTK

Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling. Interacts with HSP90; this interaction stabilizes and activates TSSK6 (By similarity). Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: TSSK6 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TSSK6 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, HCT_15, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M1, OVSAHO, Jurkat, Clone E6-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

RNA Interference


TSSK6 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SKOV3, MIAPACA2. (see details)

3D Structures


At greater than 35% identity similarity to TSSK6 there are:
80 structures (136 chains) solved
59 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TSSK6 is solved in complex with the approved drug(s):

XIN/NINTEDANIB (5MAF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TSSK6 has been screened with compounds ( bioactivities). (see details)