Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TSSK6 (Q9BXA6) - Overview - Molecular Target Synopsis


TSSK6, Testis-specific serine/threonine-protein kinase 6
Enzyme Classification
UniProt Q9BXA6

Also Known as TSSK6_HUMAN, TSSK6, SSTK

Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). Interacts with HSP90; this interaction stabilizes and activates TSSK6 (By similarity). Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: TSSK6 is active in the following subcellular-locations: cytoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TSSK6 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SN12C, HCT_15, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M1, OVSAHO, Jurkat, Clone E6-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

RNA Interference

TSSK6 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SKOV3, MIAPACA2. (see details)

3D Structures

At greater than 35% identity similarity to TSSK6 there are:
80 structures (136 chains) solved
59 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

TSSK6 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TSSK6 has been screened with 3 compounds (3 bioactivities). (see details)