Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SORBS1 (Q9BX66) - Overview - Molecular Target Synopsis

Protein


SORBS1, Sorbin and SH3 domain-containing protein 1
UniProt Q9BX66

Also Known as SRBS1_HUMAN, SORBS1, KIAA0894, KIAA1296, SH3D5

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/FAK1 and flotillin. Interacts (via SH3 domain 2) with PXN.

2MOX
SOLUTION STRUCTURE OF TANDEM SH3 DOMAIN OF SORBIN AND SH3 DOMAIN- CONTAINING PROTEIN 1
RCSB/PDB
Inspect Structure
See all 3D Structures for SORBS1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SORBS1 is active in the following subcellular-locations: adherens junction, cell junction, cell membrane, cytoplasm, cytoskeleton, focal adhesion, nucleus, nucleus matrix.
GO terms: SORBS1 is active in the following subcellular-locations: cell-cell adherens junction, cell-substrate adherens junction, centrosome, cytosol, focal adhesion, membrane raft, nuclear matrix, nucleus, plasma membrane, stress fiber, zonula adherens.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SORBS1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, MALME_3M, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, COLO 699, COLO 205

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


For SORBS1 there are:
11 structures (11 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis