Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDK19 (Q9BWU1) - Overview - Molecular Target Synopsis

Protein


CDK19, Cyclin-dependent kinase 19
Enzyme Classification 2.7.11.22
UniProt Q9BWU1

Also Known as CDK19_HUMAN, CDK19, CDC2L6, CDK11, KIAA1028

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: CDK19 is active in the following subcellular-locations: cytosol, mediator complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDK19 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, DMS 79, COR-L88

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, MCF-7

(see details)

RNA Interference


CDK19 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MG63, HS578T. (see details)

3D Structures


At greater than 90% identity similarity to CDK19 there are:
25 structures (25 chains) solved
24 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

CDK19 is solved in complex with the approved drug(s):

BAX/SORAFENIB (3RGF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDK19 has been screened with 142 compounds (223 bioactivities), 8 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)