Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CDK19 (Q9BWU1) - Overview - Molecular Target Synopsis


CDK19, Cyclin-dependent kinase 19
Enzyme Classification
UniProt Q9BWU1

Also Known as CDK19_HUMAN, CDK19, CDC2L6, CDK11, KIAA1028

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: CDK19 is active in the following subcellular-locations: cytosol, mediator complex, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CDK19 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, DMS 79, COR-L88

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, MCF-7

(see details)

RNA Interference

CDK19 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MG63, HS578T. (see details)

3D Structures

At greater than 90% identity similarity to CDK19 there are:
25 structures (25 chains) solved
24 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

CDK19 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CDK19 has been screened with 142 compounds (223 bioactivities), 8 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)