Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IFT27 (Q9BW83) - Overview - Molecular Target Synopsis

Protein


IFT27, Intraflagellar transport protein 27 homolog
UniProt Q9BW83

Also Known as IFT27_HUMAN, IFT27, RABL4, RAYL

Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. Component of the IFT complex B, at least composed of IFT20, IFT25/HSPB11, IFT27, IFT52, IFT57, IFT74, IFT81, IFT88 and TRAF3IP1 (PubMed:25443296). Interacts with IFT25/HSPB11 (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (By similarity). Interacts with ARL6; recognizes and binds with the GTP-free form of ARL6 (PubMed:25443296).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: IFT27 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, flagellum.
GO terms: IFT27 is active in the following subcellular-locations: centrosome, ciliary tip, cilium, cytoplasm, intraciliary transport particle B, motile cilium, sperm flagellum, sperm midpiece, sperm principal piece.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IFT27 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-361, MDA-MB-134-VI, NCI-H345

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, HUVEC

(see details)

3D Structures


At greater than 35% identity similarity to IFT27 there are:
20 structures (33 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis