IFT27 (Q9BW83) - Overview - Molecular Target Synopsis
IFT27, Intraflagellar transport protein 27 homolog
Also Known as IFT27_HUMAN, IFT27, RABL4, RAYL
Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. Component of the IFT complex B, at least composed of IFT20, IFT25/HSPB11, IFT27, IFT52, IFT57, IFT74, IFT81, IFT88 and TRAF3IP1 (PubMed:25443296). Interacts with IFT25/HSPB11 (By similarity). Interacts with RABL2/RABL2A; binding is equal in the presence of GTP or GDP (By similarity). Interacts with ARL6; recognizes and binds with the GTP-free form of ARL6 (PubMed:25443296).
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UniProt: IFT27 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, flagellum.
GO terms: IFT27 is active in the following subcellular-locations: centrosome, ciliary tip, cilium, cytoplasm, intraciliary transport particle B, motile cilium, sperm flagellum, sperm midpiece, sperm principal piece.