Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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TRMT61B (Q9BVS5) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2B25_B tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 62.8 30.7 Yes No
2 bound 1.77 77.7 26 No No
3 empty 2.39 57.2 18.3 No No
4 empty 2.19 62.4 18 No No
5 empty 1.76 66.6 12.8 No No
6 empty 1.65 72.8 10.8 No No
7 empty 2.17 63.7 10.8 No No
8 empty 1.75 72.4 8.9 No No
9 empty 2.1 61.8 14.7 No No
10 empty 2.92 76.6 8.5 No No
2B25_A tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 66.3 35.8 Yes No
2 bound 1.66 77 27.4 Yes No
3 empty 2.41 63.3 29.2 No No
4 empty 2.04 64.3 21.8 No No
5 empty 2.06 69.8 14.9 No No
6 empty 1.86 64.4 10.7 No No
7 empty 1.76 63.9 9.2 No No
8 empty 2.91 71.3 6.8 No No
9 empty 1.74 73.1 9 No No
10 empty 2.05 68.2 10.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2B25_A (127699) tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, tRNA(1-methyladenosine) methyltransferase-like 2.3Å Yes No
2B25_A (4186983) tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, tRNA(1-methyladenosine) methyltransferase-like (Homo Multimer) 2.3Å Yes No
2B25_B (4186983) tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, tRNA(1-methyladenosine) methyltransferase-like (Homo Multimer) 2.3Å Yes No
2B25_B (127700) tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial S-adenosyl-L-methionine-dependent methyltransferases, S-adenosyl-L-methionine-dependent methyltransferases, tRNA(1-methyladenosine) methyltransferase-like 2.3Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


TRMT61B is involved in 3 interactions in the network.


Druggability
Overall Druggability Percentile: 58.72
Druggability for Cancer Therapeutics: 78.09
Druggability for Other Therapeutics: 22.53
Cancer-Associated
Cancer-associated percentile : 36.70
Network Articulation Point
Is TRMT61B critical for communication in the network?


Detailed Graph Legend:Help