Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRMT61B (Q9BVS5) - Overview - Molecular Target Synopsis

Protein


TRMT61B, tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
Enzyme Classification 2.1.1.220
UniProt Q9BVS5

Also Known as TR61B_HUMAN, TRMT61B

Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). Homooligomer; in contrast to TRMT61A, does not form a heterotetramer.

2B25
HUMAN PUTATIVE TRNA(1-METHYLADENOSINE)METHYLTRANSFERASE
RCSB/PDB
Inspect Structure
See all 3D Structures for TRMT61B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRMT61B is active in the following subcellular-locations: mitochondrion.
GO terms: TRMT61B is active in the following subcellular-locations: mitochondrial matrix, mitochondrion, tRNA (m1A) methyltransferase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRMT61B has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, MALME_3M, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OvCA 432, VMRC-LCD, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, NHLF, A549

(see details)

3D Structures


For TRMT61B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis