Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIOK2 (Q9BVS4) - Overview - Molecular Target Synopsis

Protein


RIOK2, Serine/threonine-protein kinase RIO2
Enzyme Classification 2.7.11.1
UniProt Q9BVS4

Also Known as RIOK2_HUMAN, RIOK2, RIO2

Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). Associated with late 40S pre-ribosomal particles (PubMed:16037817, PubMed:21081503). Interacts with PLK1 (via its N-terminus) (PubMed:21880710).

6FDM
HUMAN RIO2 KINASE STRUCTURE
RCSB/PDB
Inspect Structure
See all 3D Structures for RIOK2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RIOK2 is active in the following subcellular-locations: cytoplasm.
GO terms: RIOK2 is active in the following subcellular-locations: cytoplasm, cytosol, nucleoplasm, nucleus, preribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIOK2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, LOXIMVI, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SR-786, TYK-nu, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

RNA Interference


RIOK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB157, SAOS2. (see details)

3D Structures


For RIOK2 there are:
7 structures (21 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RIOK2 has been screened with 280 compounds (333 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)