Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RIOK2 (Q9BVS4) - Overview - Molecular Target Synopsis


RIOK2, Serine/threonine-protein kinase RIO2
Enzyme Classification
UniProt Q9BVS4

Also Known as RIOK2_HUMAN, RIOK2, RIO2

Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). Associated with late 40S pre-ribosomal particles (PubMed:16037817, PubMed:21081503). Interacts with PLK1 (via its N-terminus) (PubMed:21880710).

Inspect Structure
See all 3D Structures for RIOK2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RIOK2 is active in the following subcellular-locations: cytoplasm.
GO terms: RIOK2 is active in the following subcellular-locations: cytoplasm, cytosol, nucleoplasm, nucleus, preribosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RIOK2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: RPMI_8226, LOXIMVI, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SR-786, TYK-nu, SUM 1315M02

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

RNA Interference

RIOK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB157, SAOS2. (see details)

3D Structures

For RIOK2 there are:
7 structures (21 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RIOK2 has been screened with 280 compounds (333 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (8 bioactivities). (see details)