Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DUSP26 (Q9BV47) - Overview - Molecular Target Synopsis

Protein


DUSP26, Dual specificity protein phosphatase 26
Enzyme Classification 3.1.3.16
UniProt Q9BV47

Also Known as DUS26_HUMAN, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Interacts with HSF4.

5GTJ
CRYSTAL STRUCTURE OF CATALYTICALLY ACTIVE FORM OF HUMAN DUSP26
RCSB/PDB
Inspect Structure
See all 3D Structures for DUSP26

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
211ENSG00000133878ENST00000256261, ENST00000523956ENSP00000256261, ENSP00000429176Q9BV47-1
152ENSG00000133878ENST00000522982ENSP00000430922
86Q9BV47-2

Sub-cellular localization


UniProt: DUSP26 is active in the following subcellular-locations: cytoplasm, golgi apparatus, nucleus.
GO terms: DUSP26 is active in the following subcellular-locations: cytoplasm, extracellular exosome, Golgi apparatus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DUSP26 has gain in 4 cell-lines, loss in 10 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: DU_145, PC_3, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-21H, RPMI 2650, NCI-H1092

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For DUSP26 there are:
4 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DUSP26 has been screened with 14 compounds (14 bioactivities). (see details)