Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD6 (Q9BV23) - Overview - Molecular Target Synopsis

Protein


ABHD6, Monoacylglycerol lipase ABHD6
Enzyme Classification 3.1.1.23
UniProt Q9BV23

Also Known as ABHD6_HUMAN, ABHD6

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABHD6 is active in the following subcellular-locations: late endosome membrane, lysosome membrane, mitochondrion membrane.
GO terms: ABHD6 is active in the following subcellular-locations: AMPA glutamate receptor complex, GABA-ergic synapse, glutamatergic synapse, integral component of membrane, integral component of postsynaptic membrane, late endosome membrane, lysosomal membrane, mitochondrial membrane, mitochondrion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD6 has gain in 1 cell-lines, loss in 10 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, MDA_MB_435, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-673, MHH-ES-1, SW 480

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, NHEK, HSMM

(see details)


Screening and Chemistry


ABHD6 has been screened with 119 compounds (183 bioactivities), 25 compounds have bioactivities that show binding affinity of <= 500nM (39 bioactivities). (see details)