Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABHD6 (Q9BV23) - Overview - Molecular Target Synopsis


ABHD6, Monoacylglycerol lipase ABHD6
Enzyme Classification
UniProt Q9BV23

Also Known as ABHD6_HUMAN, ABHD6

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ABHD6 is active in the following subcellular-locations: membrane, mitochondrion.
GO terms: ABHD6 is active in the following subcellular-locations: AMPA glutamate receptor complex, GABA-ergic synapse, glutamatergic synapse, integral component of membrane, integral component of postsynaptic membrane, mitochondrion, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABHD6 has gain in 1 cell-lines, loss in 10 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MDA_N, MDA_MB_435, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-673, MHH-ES-1, SW 480

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, NHEK, HSMM

(see details)

Screening and Chemistry

ABHD6 has been screened with 87 compounds (151 bioactivities), 6 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)