ABHD6 (Q9BV23) - Overview - Molecular Target Synopsis
ABHD6, Monoacylglycerol lipase ABHD6
Enzyme Classification 22.214.171.124
Also Known as ABHD6_HUMAN, ABHD6
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|337||ENSG00000163686||ENST00000295962, ENST00000478253||ENSP00000295962, ENSP00000420315||Q9BV23-1|
UniProt: ABHD6 is active in the following subcellular-locations: late endosome membrane, lysosome membrane, mitochondrion membrane.
GO terms: ABHD6 is active in the following subcellular-locations: AMPA glutamate receptor complex, GABA-ergic synapse, glutamatergic synapse, integral component of membrane, integral component of postsynaptic membrane, late endosome membrane, lysosomal membrane, mitochondrial membrane, mitochondrion, plasma membrane.