Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABHD14A (Q9BUJ0) - Overview - Molecular Target Synopsis

Protein


ABHD14A, Protein ABHD14A
Enzyme Classification 3.-.-.-
UniProt Q9BUJ0

Also Known as ABHEA_HUMAN, ABHD14A

Possible role in granule neuron development.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABHD14A is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: ABHD14A is active in the following subcellular-locations: cytoplasm, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABHD14A has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SK_MEL_2, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A4/Fuk, KMS-21BM, KHM-1B

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, A549, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to ABHD14A there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis