Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CPLANE2 (Q9BU20) - Overview - Molecular Target Synopsis

Protein


CPLANE2, Ciliogenesis and planar polarity effector 2
UniProt Q9BU20

Also Known as CPLN2_HUMAN, CPLANE2, C1orf89, RSG1

Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
258ENSG00000132881ENST00000375599ENSP00000364749Q9BU20-1
109ENSG00000132881ENST00000434014ENSP00000406390

Sub-cellular localization


UniProt: CPLANE2 is active in the following subcellular-locations: cilium basal body, cytoplasm, cytoskeleton.
GO terms: CPLANE2 is active in the following subcellular-locations: ciliary basal body, cytoplasm, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CPLANE2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)