Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBM42 (Q9BTD8) - Overview - Molecular Target Synopsis

Protein


RBM42, RNA-binding protein 42
UniProt Q9BTD8

Also Known as RBM42_HUMAN, RBM42

Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Interacts with HNRNPK.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RBM42 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: RBM42 is active in the following subcellular-locations: cytoplasm, nucleus, ribonucleoprotein complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBM42 has gain in 7 cell-lines, loss in 2 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, OVCAR_3, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1299, G84, HCC4011

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, HeLa-S3

(see details)

3D Structures


At greater than 35% identity similarity to RBM42 there are:
8 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis