Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAA11 (Q9BSU3) - Overview - Molecular Target Synopsis

Protein


NAA11, N-alpha-acetyltransferase 11
Enzyme Classification 2.3.1.255
UniProt Q9BSU3

Also Known as NAA11_HUMAN, NAA11, ARD1B, ARD2

Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
233ENSG00000156269ENST00000286794ENSP00000286794
229Q9BSU3-1
111ENSG00000156269ENST00000511542ENSP00000422022

Sub-cellular localization


UniProt: NAA11 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: NAA11 is active in the following subcellular-locations: NatA complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAA11 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMM-1, K-562, A4/Fuk

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to NAA11 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis