Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATG101 (Q9BSB4) - Overview - Molecular Target Synopsis

Protein


ATG101, Autophagy-related protein 101
UniProt Q9BSB4

Also Known as ATGA1_HUMAN, ATG101, C12orf44

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. Interacts with ATG13 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13 (PubMed:19287211, PubMed:19597335).

5XV4
CRYSTAL STRUCTURE OF ATG101-ATG13HORMA
RCSB/PDB
Inspect Structure
See all 3D Structures for ATG101

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ATG101 is active in the following subcellular-locations: cytoplasm, preautophagosomal structure.
GO terms: ATG101 is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, phagophore assembly site.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATG101 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, SW 480, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HeLa-S3

(see details)

3D Structures


For ATG101 there are:
7 structures (17 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis