Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARHGAP9 (Q9BRR9) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2P0D_A Rho GTPase-activating protein 9 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 64.1 19.7 No No
2 empty 2.79 73.4 10.7 No No
3 empty 2.52 59 14.4 No No
4 empty 1.8 53.9 11.2 No No
5 empty 2.21 68.4 9.2 No No
6 empty 2.13 67.8 8 No No
7 empty 1.77 59.7 13.4 No No
8 empty 2.89 55 11.2 No No
9 empty 2.81 49.4 9.9 No No
10 empty 2.84 57.4 8.9 No No
2P0H_A Rho GTPase-activating protein 9 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 70.2 18.1 No No
2 empty 2.22 62.7 24.1 No No
3 empty 2.69 68.8 17 No No
4 empty 2.12 62.5 13.6 No No
5 empty 2.34 64.6 13 No No
6 empty 2.74 65 8.6 No No
7 empty 2.39 60.4 8.5 No No
8 bound 2.73 55.6 11.7 No No
9 empty 1.93 56.7 9.7 No No
10 empty 3.27 55.9 8.4 No No
2P0F_A Rho GTPase-activating protein 9 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 57.1 28.1 Yes No
2 empty 2.45 61.9 21 No No
3 empty 2.71 69.7 17.3 No No
4 empty 2.03 66.3 15.5 No No
5 empty 1.67 61.1 15.8 No No
6 empty 2.75 66.3 11.8 No No
7 bound 2.88 56.6 12.1 No No
8 empty 2.25 74.4 10.3 No No
9 empty 1.87 90.5 10.3 Yes No
10 empty 2.18 70.2 8.9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2P0D_A (3170257) Rho GTPase-activating protein 9 PFAM, PFAM, PFAM PH 1.8Å No No
2P0F_A (3170259) Rho GTPase-activating protein 9 PFAM, PFAM, PFAM PH 1.9Å Yes No
2P0H_A (3170261) Rho GTPase-activating protein 9 PFAM, PFAM, PFAM PH 1.9Å No No
Ligand-based Druggability Score: 1.15
Ligand-based Druggability Score Percentile: 92%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ARHGAP9 is involved in 8 interactions in the network.


Druggability
Overall Druggability Percentile: 81.70
Druggability for Cancer Therapeutics: 84.14
Druggability for Other Therapeutics: 81.44
Cancer-Associated
Cancer-associated percentile : 76.72
Network Articulation Point
Is ARHGAP9 critical for communication in the network?


Detailed Graph Legend:Help