Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARHGAP9 (Q9BRR9) - Overview - Molecular Target Synopsis

Protein


ARHGAP9, Rho GTPase-activating protein 9
UniProt Q9BRR9

Also Known as RHG09_HUMAN, ARHGAP9

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. Interacts with FASLG.

2P0D
ARHGAP9 PH DOMAIN IN COMPLEX WITH INS(1,4,5)P3
RCSB/PDB
Inspect Structure
See all 3D Structures for ARHGAP9

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ARHGAP9 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular region, secretory granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARHGAP9 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, NCI_H522, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UKE-1, HEL, COR-L26

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, CD14-positive monocyte, CD34-positive mobilized cell

(see details)

3D Structures


For ARHGAP9 there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARHGAP9 has been screened with compounds ( bioactivities). (see details)