Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AIFM2 (Q9BRQ8) - Overview - Molecular Target Synopsis

Protein


AIFM2, Apoptosis-inducing factor 2
Enzyme Classification 1.-.-.-
UniProt Q9BRQ8

Also Known as AIFM2_HUMAN, AIFM2, AMID, PRG3

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
373ENSG00000042286ENST00000307864, ENST00000373248ENSP00000312370, ENSP00000362345Q9BRQ8-1
336Q9BRQ8-2

Sub-cellular localization


UniProt: AIFM2 is active in the following subcellular-locations: cytoplasm, membrane, mitochondrion outer membrane.
GO terms: AIFM2 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular space, integral component of membrane, lipid droplet, mitochondrial outer membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AIFM2 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, HCC_2998, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, NCI-H520, SW 48

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, HeLa-S3

(see details)

RNA Interference


AIFM2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)