Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

AIFM2 (Q9BRQ8) - Overview - Molecular Target Synopsis


AIFM2, Apoptosis-inducing factor 2
Enzyme Classification 1.-.-.-
UniProt Q9BRQ8

Also Known as AIFM2_HUMAN, AIFM2, AMID, PRG3

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
373ENSG00000042286ENST00000307864, ENST00000373248ENSP00000312370, ENSP00000362345Q9BRQ8-1

Sub-cellular localization

UniProt: AIFM2 is active in the following subcellular-locations: cytoplasm, membrane, mitochondrion outer membrane.
GO terms: AIFM2 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular space, integral component of membrane, lipid droplet, mitochondrial outer membrane, mitochondrion.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project AIFM2 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: U251, HCC_2998, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, NCI-H520, SW 48

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, HeLa-S3

(see details)

RNA Interference

AIFM2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)