Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CPPED1 (Q9BRF8) - Overview - Molecular Target Synopsis

Protein


CPPED1, Serine/threonine-protein phosphatase CPPED1
Enzyme Classification 3.1.3.16
UniProt Q9BRF8

Also Known as CPPED_HUMAN, CPPED1, CSTP1

Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CPPED1 is active in the following subcellular-locations: cytoplasm.
GO terms: CPPED1 is active in the following subcellular-locations: azurophil granule lumen, cytosol, extracellular region, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CPPED1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, HEL, A172

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HUVEC, BJ

(see details)