Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DPYSL5 (Q9BPU6) - Overview - Molecular Target Synopsis

Protein


DPYSL5, Dihydropyrimidinase-related protein 5
UniProt Q9BPU6

Also Known as DPYL5_HUMAN, DPYSL5, CRMP5, ULIP6

May have a function in neuronal differentiation and/or axon growth. Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4.

4B90
CRYSTAL STRUCTURE OF WT HUMAN CRMP-5
RCSB/PDB
Inspect Structure
See all 3D Structures for DPYSL5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: DPYSL5 is active in the following subcellular-locations: cytoplasm.
GO terms: DPYSL5 is active in the following subcellular-locations: cytosol, dendrite, neuronal cell body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DPYSL5 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, HCT_116, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H187, KELLY, DMS 79

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


For DPYSL5 there are:
3 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DPYSL5 has been screened with compounds ( bioactivities). (see details)