Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MET2A (Q9AXT8) - Overview - Molecular Target Synopsis

Protein


MET2A, DNA (cytosine-5)-methyltransferase 1
Enzyme Classification 2.1.1.37
UniProt Q9AXT8

Also Known as CMT1_MAIZE, MET2A

Involved in the CpXpG methylation and in gene silencing.

4FSX
CRYSTAL STRUCTURE OF SE-SUBSTITUTED ZEA MAYS ZMET2 IN COMPLEX WITH SAH
RCSB/PDB
Inspect Structure
See all 3D Structures for MET2A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
912Q9AXT8-1

Sub-cellular localization


UniProt: MET2A is active in the following subcellular-locations: nucleus.
GO terms: MET2A is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MET2A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For MET2A there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis