Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

agaA (Q9ALJ4) - Overview - Molecular Target Synopsis

Protein


agaA, Alpha-galactosidase AgaA
Enzyme Classification 3.2.1.22
UniProt Q9ALJ4

Also Known as AGAA_GEOSE, agaA

Hydrolyzes the short-chain alpha-galactosaccharides raffinose and stachyose. Homotetramer.

4FNP
CRYSTAL STRUCTURE OF GH36 ALPHA-GALACTOSIDASE AGAA A355E FROM GEOBACILLUS STEAROTHERMOPHILUS
RCSB/PDB
Inspect Structure
See all 3D Structures for agaA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation


In COSMIC - Cell Lines Project agaA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For agaA there are:
5 structures (20 chains) solved
3 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

agaA is solved in complex with the approved drug(s):

DGJ/MIGALASTAT (4FNS_A, 4FNS_B, 4FNS_C, 4FNS_D),
FRU/FRUCTOSE (4FNU_A, 4FNU_B, 4FNU_C, 4FNU_D).

(see details)
Molecular Target 3D Synopsis