Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(Q99T13) - Overview - Molecular Target Synopsis

Protein


, Putative multidrug export ATP-binding/permease protein SAV1866
Enzyme Classification 3.6.3.-
UniProt Q99T13

Also Known as Y1866_STAAM

May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. Homodimer.

4A82
FITTED MODEL OF STAPHYLOCOCCUS AUREUS SAV1866 MODEL ABC TRANSPORTER IN THE HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VOLUME MAP EMD-1966.
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: is active in the following subcellular-locations: cell membrane.
GO terms: is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
3 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with compounds ( bioactivities). (see details)