Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Tdrd1 (Q99MV1) - Overview - Molecular Target Synopsis

Protein


Tdrd1, Tudor domain-containing protein 1
UniProt Q99MV1

Also Known as TDRD1_MOUSE, Tdrd1

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with MAEL. Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues). Interacts with TDRD12.

4B9W
STRUCTURE OF EXTENDED TUDOR DOMAIN TD3 FROM MOUSE TDRD1 IN COMPLEX WITH MILI PEPTIDE CONTAINING DIMETHYLARGININE 45.
RCSB/PDB
Inspect Structure
See all 3D Structures for Tdrd1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1172Q99MV1-1

Sub-cellular localization


UniProt: Tdrd1 is active in the following subcellular-locations: cytoplasm.
GO terms: Tdrd1 is active in the following subcellular-locations: chromatoid body, cytoplasm, cytosol, P granule, pi-body, ribonucleoprotein complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Tdrd1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Tdrd1 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis