Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA3 (Q99758) - Overview - Molecular Target Synopsis

Protein


ABCA3, ATP-binding cassette sub-family A member 3
UniProt Q99758

Also Known as ABCA3_HUMAN, ABCA3, ABC3

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA3 is active in the following subcellular-locations: membrane.
GO terms: ABCA3 is active in the following subcellular-locations: alveolar lamellar body, alveolar lamellar body membrane, extracellular space, integral component of membrane, intracellular membrane-bounded organelle, lamellar body membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA3 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, SR, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H810, NCI-H1092, NCI-H187

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, HUVEC

(see details)

3D Structures


At greater than 35% identity similarity to ABCA3 there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA3 has been screened with compounds ( bioactivities). (see details)