MDFI (Q99750) - Overview - Molecular Target Synopsis
MDFI, MyoD family inhibitor
Also Known as MDFI_HUMAN, MDFI
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. The C-terminus interacts with AXIN1 and LEF1 (By similarity). Interacts with CCNT2 (PubMed:17289077).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|246||ENSG00000112559||ENST00000230321, ENST00000373051||ENSP00000230321, ENSP00000362142||Q99750-1|
UniProt: MDFI is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: MDFI is active in the following subcellular-locations: cytoplasm, nucleus.