Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MCHR1 (Q99705) - Overview - Molecular Target Synopsis

Protein


MCHR1, Melanin-concentrating hormone receptor 1
UniProt Q99705

Also Known as MCHR1_HUMAN, MCHR1, GPR24, SLC1

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Interacts with NCDN.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
422ENSG00000128285ENST00000249016ENSP00000249016Q5IJ49-1, Q99705-1
296ENSG00000128285ENST00000381433ENSP00000370841

Sub-cellular localization


UniProt: MCHR1 is active in the following subcellular-locations: cell membrane.
GO terms: MCHR1 is active in the following subcellular-locations: ciliary membrane, integral component of plasma membrane, non-motile cilium, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MCHR1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, SN12C, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, SK-MEL-1, LXFL529

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


MCHR1 has been screened with 3672 compounds (5172 bioactivities), 2939 compounds have bioactivities that show binding affinity of <= 500nM (3970 bioactivities). (see details)