Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MCHR1 (Q99705) - Overview - Molecular Target Synopsis


MCHR1, Melanin-concentrating hormone receptor 1
UniProt Q99705

Also Known as MCHR1_HUMAN, MCHR1, GPR24, SLC1

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Interacts with NCDN.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
422ENSG00000128285ENST00000249016ENSP00000249016Q5IJ49-1, Q99705-1

Sub-cellular localization

UniProt: MCHR1 is active in the following subcellular-locations: cell membrane.
GO terms: MCHR1 is active in the following subcellular-locations: ciliary membrane, integral component of plasma membrane, non-motile cilium, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MCHR1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MOLT_4, SN12C, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, SK-MEL-1, LXFL529

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

Screening and Chemistry

MCHR1 has been screened with 3672 compounds (5172 bioactivities), 2939 compounds have bioactivities that show binding affinity of <= 500nM (3970 bioactivities). (see details)