Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PITX2 (Q99697) - Overview - Molecular Target Synopsis

Protein


PITX2, Pituitary homeobox 2
UniProt Q99697

Also Known as PITX2_HUMAN, PITX2, ARP1, RGS, RIEG, RIEG1

Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo.

2LKX
NMR STRUCTURE OF THE HOMEODOMAIN OF PITX2 IN COMPLEX WITH A TAATCC DNA BINDING SITE
RCSB/PDB
Inspect Structure
See all 3D Structures for PITX2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PITX2 is active in the following subcellular-locations: nucleus.
GO terms: PITX2 is active in the following subcellular-locations: nucleoplasm, nucleus, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PITX2 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_15, EKVX, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1734, SJCRH30, CL-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


For PITX2 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PITX2 has been screened with compounds ( bioactivities). (see details)