Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MGLL (Q99685) - Overview - Molecular Target Synopsis

Protein


MGLL, Monoglyceride lipase
Enzyme Classification 3.1.1.23
UniProt Q99685

Also Known as MGLL_HUMAN, MGLL

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). Homodimer.

5ZUN
CRYSTAL STRUCTURE OF HUMAN MONOACYLGLYCEROL LIPASE IN COMPLEX WITH COMPOUND 3L
RCSB/PDB
Inspect Structure
See all 3D Structures for MGLL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MGLL is active in the following subcellular-locations: cytoplasm, cytosol, membrane.
GO terms: MGLL is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, extrinsic component of membrane, membrane, nucleoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MGLL has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, A498, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-24, MDA-MB-435, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, IMR-90, BJ

(see details)

3D Structures


For MGLL there are:
8 structures (14 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MGLL has been screened with 701 compounds (1059 bioactivities), 144 compounds have bioactivities that show binding affinity of <= 500nM (212 bioactivities). (see details)