Molecular Target Synopsis
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MAP3K5 (Q99683) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed42
Chains with at least one site assessed as druggable using the strict criteria20
Chains with at least one site assessed as druggable using the relaxed criteria42


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6E2M_B Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 67.3 42.2 Yes Yes
2 empty 2.33 62.4 34.4 No No
3 empty 2.26 63.2 22.6 No No
4 empty 2.08 66.4 20.5 No No
5 empty 2.45 65 20.5 No No
6 empty 2 62.6 13.6 No No
7 empty 2.13 73.1 8.4 No No
8 empty 2.61 59 13.2 No No
9 empty 1.97 64.6 11.3 No No
10 empty 2.5 48.7 8.6 No No
4BIC_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 65.2 50.2 Yes No
2 empty 2.17 66.5 23 No No
3 empty 2.17 70.5 16.3 No No
4 empty 2.06 73.4 13.1 No No
5 empty 2.39 54 14.7 No No
6 empty 2.33 59.5 17.1 No No
7 empty 1.96 67.9 11.6 No No
8 empty 1.39 98.6 0 Yes No
9 empty 1.99 62.1 9.1 No No
10 empty 2.42 53.6 10.9 No No
5VIL_C Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 65.6 40.1 Yes No
2 empty 2.19 74.6 17.8 No No
3 empty 2.37 68.6 29.6 No No
4 empty 2.33 64 27.6 No No
5 empty 2.23 65.7 21.3 No No
6 empty 2.34 65.6 23 No No
7 empty 1.91 65.3 14.4 No No
8 empty 1.97 69.7 13.3 No No
9 empty 2.08 62.1 12.8 No No
10 empty 2.13 63.2 15.9 No No
2CLQ_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 64.3 42.8 Yes No
2 empty 1.43 62.8 32.4 No No
3 empty 2.15 66.2 24.3 No No
4 empty 2.3 68.3 15.6 No No
5 empty 1.86 69.1 11.4 No No
6 empty 2.33 64.4 14.5 No No
7 empty 2.01 57.5 10.9 No No
8 empty 2.67 64.9 9.2 No No
9 empty 2 63.4 10.4 No No
10 empty 2.4 74.5 9.1 No No
4BID_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 67.4 47.5 Yes Yes
2 empty 1.96 68.1 14.9 No No
3 empty 2.02 63.3 15.2 No No
4 empty 2.15 71.7 15.6 No No
5 empty 1.96 71.9 12.4 No No
6 empty 1.95 71.4 11.4 No No
7 empty 2.4 52.6 16 No No
8 empty 2.4 61.1 16.9 No No
9 empty 1.75 68.3 12.1 No No
10 empty 1.62 60.2 14.9 No No
5V24_B Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 66.4 41.3 Yes Yes
2 empty 2.41 63.8 27.1 No No
3 empty 2.2 63 21.9 No No
4 empty 2.04 66.5 20.2 No No
5 empty 2.18 72.3 17.1 No No
6 empty 2 58.9 14.2 No No
7 empty 2.3 59.1 14.3 No No
8 empty 2.33 64.5 10.2 No No
9 empty 2.49 62.3 16.7 No No
10 empty 2.56 67.4 12.9 No No
6E2O_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 67.4 41.5 Yes Yes
2 empty 2.26 65.1 24.2 No No
3 empty 2.08 71.1 15.9 No No
4 empty 1.9 69.7 12.5 No No
5 empty 2.06 68.9 13.9 No No
6 empty 2.49 64.9 15.4 No No
7 empty 2.19 67.4 11.8 No No
8 empty 2.69 60.8 21.9 No No
9 empty 1.93 60.7 14.2 No No
10 empty 2.2 54.6 15.5 No No
4BF2_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 63.9 37.1 Yes No
2 empty 2.11 66.2 31.8 No No
3 empty 2.35 66.5 28.1 No No
4 empty 1.87 67.6 17.6 No No
5 empty 2.31 68.4 11.3 No No
6 empty 1.96 62.1 12.3 No No
7 empty 2.03 63.6 12.1 No No
8 empty 2.6 58.8 15.5 No No
9 empty 2.13 68.8 12.2 No No
10 empty 1.75 69.2 9 No No
5VIL_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 65.7 32.9 Yes No
2 empty 1.94 60.4 28 No No
3 empty 1.93 63.7 18.3 No No
4 empty 1.96 60.9 20.3 No No
5 empty 1.83 54.9 16.8 No No
6 empty 1.76 70.1 13.1 No No
7 empty 1.94 64.6 11.5 No No
8 empty 1.86 61.7 10.7 No No
9 empty 2.48 61 12.1 No No
10 empty 2.05 60.1 12.5 No No
5VIL_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 62.9 25.2 Yes No
2 bound 2.11 66.4 30.7 No No
3 empty 2.09 61.8 20.1 No No
4 empty 1.88 79.3 12.1 No No
5 empty 1.89 62.7 11.3 No No
6 empty 1.85 63.1 11.6 No No
7 empty 2.13 67.1 11 No No
8 empty 2.43 59.2 16.3 No No
9 empty 2.19 67.2 10.3 No No
10 empty 2.05 67 9.4 No No
4BIB_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 67.9 40.5 Yes Yes
2 bound 2 67.8 18.8 No No
3 empty 2.14 70 18 No No
4 empty 2.08 63.4 14.1 No No
5 empty 2.31 65.1 21.3 No No
6 empty 2.09 59.9 14.1 No No
7 empty 2.36 53.2 15.2 No No
8 empty 2.36 59.3 15.6 No No
9 empty 2.02 64.1 8.6 No No
10 empty 1.74 60.3 17 No No
5UOR_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 67.4 34.9 Yes Yes
2 empty 2.04 58.8 17.9 No No
3 bound 2.11 54.1 24.6 No No
4 empty 2.04 61 16.2 No No
5 empty 2 60.7 13.9 No No
6 empty 1.4 57.6 16 No No
7 empty 1.85 61.2 11.4 No No
8 empty 2.2 54 17.1 No No
9 empty 1.81 65.2 10.7 No No
10 empty 1.62 67.3 9.8 No No
4BIE_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 66.4 41.2 Yes Yes
2 empty 1.99 66.7 23.3 No No
3 empty 1.99 69.1 17.5 No No
4 empty 2.03 66.1 15 No No
5 empty 2.23 67.8 18.7 No No
6 empty 2.57 59.9 23 No No
7 empty 1.65 69.5 11.1 No No
8 empty 2.06 59.4 20.4 No No
9 empty 2.39 50.3 15.7 No No
10 empty 2.32 61.3 16.6 No No
5ULM_B Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 67.5 44.7 Yes Yes
2 empty 2.24 64.8 27 No No
3 empty 2 66.9 24.6 No No
4 empty 1.89 60.8 19.6 No No
5 empty 1.88 76.3 13.7 No No
6 empty 2.2 57.6 19.5 No No
7 empty 2.11 62.3 12.9 No No
8 empty 2.13 57.5 14 No No
9 empty 1.84 50.8 12.7 No No
10 empty 2.14 54.5 16.9 No No
4BHN_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 64.4 45.3 Yes No
2 empty 2.1 66.5 32.6 No No
3 empty 2.05 55.9 15.1 No No
4 empty 2 65.2 13.8 No No
5 empty 1.69 68.3 9.5 No No
6 empty 2.55 61.5 14.9 No No
7 empty 2.22 60.9 11.9 No No
8 empty 2.37 53.6 14.4 No No
9 empty 1.79 58.9 13.5 No No
10 empty 2.23 63.6 10.3 No No
3VW6_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 65.7 47.4 Yes No
2 empty 2.06 66 17.2 No No
3 empty 2.15 63.1 21 No No
4 empty 2.06 63.4 11.3 No No
5 empty 1.9 66.5 11 No No
6 empty 2.1 68.9 12.5 No No
7 empty 2.36 59.8 17.2 No No
8 empty 1.69 65 9.1 No No
9 empty 2.85 65.9 11.3 No No
10 empty 2.47 77.2 8.4 No No
5VIO_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 65.1 51 Yes No
2 empty 2.15 65.9 23.4 No No
3 empty 2.1 69.2 25.7 No No
4 empty 2.05 60.8 18.1 No No
5 empty 1.76 69.4 14.3 No No
6 empty 2.3 64.3 15.2 No No
7 empty 2.41 63.1 14.4 No No
8 empty 2.39 63.9 12.7 No No
9 empty 2.56 62.5 14.1 No No
10 empty 2.03 63.4 12 No No
4BF2_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 67.1 42 Yes Yes
2 empty 2.34 63.1 33.7 No No
3 empty 2.13 76.1 22.7 No No
4 empty 1.97 63.9 16.7 No No
5 empty 2.24 51.2 15.4 No No
6 empty 1.91 68.6 10.6 No No
7 empty 2.37 61.5 14.5 No No
8 empty 2.06 61.6 11.3 No No
9 empty 1.98 59.8 9.6 No No
10 empty 2.24 69.7 8.9 No No
5V19_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 63.6 40.2 Yes No
2 empty 2.14 66.1 20.5 No No
3 empty 2.03 68.7 28.3 No No
4 empty 2.13 65.3 22.6 No No
5 empty 2.41 66.3 18.8 No No
6 empty 1.95 68.3 14.5 No No
7 empty 2.46 58.4 16.1 No No
8 empty 1.94 56.3 10.9 No No
9 empty 2.34 54.3 13.7 No No
10 empty 1.98 63.9 9 No No
6E2N_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 65.9 40.9 Yes No
2 empty 2.34 58.5 27.1 No No
3 empty 2.09 69 20.9 No No
4 empty 2.11 64.6 18.6 No No
5 empty 1.9 70.9 12.2 No No
6 empty 2.53 57.7 13.8 No No
7 empty 1.87 65.3 13.1 No No
8 empty 2.51 65.8 12.7 No No
9 empty 1.97 69.6 11.4 No No
10 empty 2.46 77.9 7.6 No No
5VIO_C Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 66.4 40.2 Yes Yes
2 empty 2.13 75.5 18 No No
3 empty 2.37 66.5 26.1 No No
4 empty 2.3 65.9 23.7 No No
5 empty 2.06 63.2 22.9 No No
6 empty 2.04 66 18.6 No No
7 empty 1.85 66.2 11.3 No No
8 empty 2.03 66.9 17.1 No No
9 empty 1.89 63.4 16.4 No No
10 empty 2.18 60.8 13.1 No No
5UP3_B Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 68 32.2 Yes Yes
2 empty 1.88 68.4 33.9 No No
3 empty 1.94 65.1 20 No No
4 empty 2.4 64.5 24.2 No No
5 empty 2.18 67.8 16.4 No No
6 empty 2.22 72.3 16.2 No No
7 empty 2.05 58.1 18.1 No No
8 empty 2.03 60.5 11.1 No No
9 empty 2.58 61.3 15.9 No No
10 empty 2.27 52.6 14.7 No No
6E2M_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 68.4 41.2 Yes Yes
2 empty 2.3 67.6 27 No No
3 empty 2.3 66.9 26.7 No No
4 empty 2.05 65.8 17.1 No No
5 empty 2.5 61.1 18.3 No No
6 empty 2.12 73.8 13.1 No No
7 empty 2.04 61.4 12.3 No No
8 empty 1.91 60.7 13.5 No No
9 empty 1.93 55.5 14.4 No No
10 empty 2.62 57.4 13 No No
4BID_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 64.4 39.7 Yes No
2 empty 2.12 62 20 No No
3 empty 2.06 64.4 23.8 No No
4 empty 1.92 69.1 24.5 No No
5 empty 1.99 64 16.2 No No
6 empty 1.92 69 10.9 No No
7 empty 1.88 54.6 12.4 No No
8 empty 2.47 63.3 16.6 No No
9 empty 2.36 54.9 16.7 No No
10 empty 1.9 68.3 9.3 No No
5ULM_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 69 56.8 Yes Yes
2 empty 2 69.3 43.6 No No
3 empty 1.85 67.3 35 No No
4 empty 2.21 62.1 25.2 No No
5 empty 2.16 66.1 21.1 No No
6 empty 2.2 65.4 18.1 No No
7 empty 2.21 56.3 23.8 No No
8 empty 2.75 72.8 11.8 No No
9 empty 2.07 68.9 13.4 No No
10 empty 1.91 65.6 13 No No
3VW6_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 66 36.7 Yes No
2 empty 2.21 64.2 23.3 No No
3 empty 2.21 68.4 21 No No
4 empty 2.11 59.9 21.7 No No
5 empty 2.17 69.1 17 No No
6 empty 2.1 74.3 12.3 No No
7 empty 2.44 48.1 16.3 No No
8 empty 2.02 58.7 10.5 No No
9 empty 2.03 57.5 13.5 No No
10 empty 2.53 72.8 10.7 No No
5UP3_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 66.5 35.7 Yes Yes
2 empty 2.18 62.5 33.5 No No
3 empty 2.31 63.2 26.3 No No
4 empty 2.11 66.8 17.5 No No
5 empty 2.17 69.9 17.7 No No
6 empty 2.28 62.3 14.7 No No
7 empty 2.24 70.2 15 No No
8 empty 2.31 64.8 20.9 No No
9 empty 2.51 67.4 10.3 No No
10 empty 2.02 56.9 15 No No
2CLQ_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 68.1 43.8 Yes Yes
2 empty 2.34 63.2 32.6 No No
3 empty 2.4 69.6 19.9 No No
4 empty 1.96 64.9 17.5 No No
5 empty 2.48 52.5 20.1 No No
6 empty 1.96 67 17.1 No No
7 empty 2.48 59.6 16.9 No No
8 empty 2.14 73 12.1 No No
9 empty 2.22 66.7 13.6 No No
10 empty 2.42 80.1 7.5 No No
4BHN_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 64.5 49.1 Yes No
2 empty 2.21 67.7 20.9 No No
3 empty 1.98 67.7 19 No No
4 empty 2.04 65 16.3 No No
5 empty 2.22 71.1 18.9 No No
6 empty 2.52 50.8 20.3 No No
7 empty 1.73 66.9 9.3 No No
8 bound 2.55 68.8 11.7 No No
9 empty 2.51 60.3 14.6 No No
10 empty 2.43 72.4 6.9 No No
4BIB_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 65.7 38.9 Yes No
2 empty 2.13 64.9 31.4 No No
3 empty 2.31 67.1 23.1 No No
4 empty 1.91 68.6 14.6 No No
5 empty 2.06 64.8 14.1 No No
6 empty 2.32 53.6 13.9 No No
7 empty 2.51 60.1 14.2 No No
8 empty 1.87 67.5 9.4 No No
9 empty 2.11 61.2 10.5 No No
10 empty 1.96 64.1 10.8 No No
5VIO_D Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 66.8 45.2 Yes Yes
2 empty 2.02 65.3 27.3 No No
3 empty 2.25 66.7 19.6 No No
4 empty 1.98 67 18.6 No No
5 empty 2.14 69.3 15.8 No No
6 empty 1.99 83.2 9.8 No No
7 empty 2.5 56.4 18 No No
8 empty 2.05 59.2 17.4 No No
9 empty 2.5 60.5 12.5 No No
10 empty 2.15 62.3 10.3 No No
6E2O_B Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 66.4 40.4 Yes Yes
2 empty 1.88 62.4 16.2 No No
3 empty 2.2 67.8 14.3 No No
4 empty 2.47 63.2 17.2 No No
5 empty 1.66 77.3 10.4 No No
6 empty 1.91 58.7 14.9 No No
7 empty 2.49 58.5 13.5 No No
8 empty 2.04 62.4 9.8 No No
9 empty 2.29 56.2 14.8 No No
10 empty 2.54 67.2 13.4 No No
5VIO_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 64.9 37.6 Yes No
2 empty 2.14 64.6 25.1 No No
3 empty 2.1 68.2 25.7 No No
4 empty 2.34 63.1 28.4 No No
5 empty 2.2 62 18.1 No No
6 empty 2.11 63.2 20.6 No No
7 empty 2.57 58.7 16.1 No No
8 empty 2.09 71.4 11.2 No No
9 empty 2.19 63.7 17.1 No No
10 empty 1.93 60.9 11.8 No No
4BIE_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 64.4 44.4 Yes No
2 empty 1.98 64.4 32.2 No No
3 empty 2.27 65.9 30.1 No No
4 empty 2.04 63.7 19.5 No No
5 empty 2.53 55.6 19.3 No No
6 empty 1.93 60.6 11.6 No No
7 empty 2.59 62.6 17 No No
8 empty 2.04 54.8 12.5 No No
9 empty 2.45 63.5 8.4 No No
10 empty 1.85 57.4 13.8 No No
5UOR_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 65.6 41.5 Yes No
2 empty 2.01 61 20.4 No No
3 empty 2.11 63.3 24.5 No No
4 empty 2.07 69.1 16.6 No No
5 empty 2.03 68.7 15.9 No No
6 empty 2.64 58.5 21 No No
7 empty 2.29 64.1 13.4 No No
8 empty 2.51 60.4 17 No No
9 empty 2.58 46.3 16.7 No No
10 empty 2.02 54.9 11.3 No No
6E2N_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 67.6 39.9 Yes Yes
2 empty 2.28 63.1 30 No No
3 empty 2.26 70.1 18.8 No No
4 empty 1.99 69.4 17.4 No No
5 empty 1.95 66.1 15.1 No No
6 empty 2.55 64.7 12.8 No No
7 empty 2.23 73.6 13.7 No No
8 empty 2.1 62.6 11 No No
9 empty 2.02 59.7 12.8 No No
10 empty 2.19 72.4 11 No No
5V19_A Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 66.7 45.5 Yes Yes
2 empty 1.7 65.6 22.6 No No
3 empty 2.28 63.7 24.3 No No
4 empty 1.94 61.9 20.6 No No
5 empty 2.18 65.7 20 No No
6 empty 2.26 75.9 11.2 No No
7 empty 1.78 64.2 14 No No
8 empty 2.69 66.8 9.1 No No
9 empty 1.93 63.9 14.4 No No
10 empty 2.46 55.1 14.4 No No
4BIC_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 64.4 41.1 Yes No
2 empty 1.87 65.1 30.2 No No
3 empty 2.23 65.8 29.7 No No
4 empty 1.92 70.1 14.2 No No
5 empty 2.54 52.3 18.9 No No
6 empty 1.88 65 12.1 No No
7 empty 2.58 60 12 No No
8 empty 1.96 60.6 10.2 No No
9 empty 1.78 68.2 10.7 No No
10 empty 1.96 58.3 13.7 No No
5UOX_B Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 65.3 38.9 Yes No
2 empty 2.16 68 23.2 No No
3 empty 1.92 68.8 21.1 No No
4 empty 1.73 70.6 24.8 No No
5 empty 2.16 61.7 20.2 No No
6 empty 2.09 66.1 19.6 No No
7 empty 2.13 66.1 24.6 No No
8 empty 2.5 62.5 23.3 No No
9 empty 2.33 55.3 12.8 No No
10 empty 2.43 50.2 10 No No
5UOX_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 63.8 42.5 Yes No
2 empty 2.4 63.6 33.4 No No
3 empty 2.07 60.3 19.2 No No
4 empty 2.23 74.9 17.4 No No
5 empty 2.1 74.9 10.9 No No
6 empty 2.23 58.9 17.1 No No
7 empty 2.52 64.6 16.9 No No
8 empty 1.98 66 11.7 No No
9 empty 1.87 62.2 16.3 No No
10 empty 2.33 65.9 12.5 No No
5VIL_D Mitogen-activated protein kinase kinase kinase 5 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.04 67.9 48.6 Yes Yes
2 empty 2.41 63.4 26.2 No No
3 empty 2.28 68.4 19 No No
4 empty 2.08 67.3 19.9 No No
5 empty 1.87 70.3 11.5 No No
6 empty 2.67 58.4 20.3 No No
7 empty 2.02 59.2 15.2 No No
8 empty 2.17 64.1 14.2 No No
9 empty 2.2 63.8 10.2 No No
10 empty 2.65 56.8 13.2 No No
5V24_A Mitogen-activated protein kinase kinase kinase 5 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 65.9 32.5 Yes No
2 empty 1.72 65.4 29.8 No No
3 empty 2.42 66.9 26.3 No No
4 empty 2.33 64.8 29.2 No No
5 empty 2.14 69.9 19.3 No No
6 empty 1.99 70 13.4 No No
7 empty 2.02 69.4 13.6 No No
8 empty 2.45 52.6 14.4 No No
9 empty 2.03 63.2 14.1 No No
10 empty 2.44 61.9 13.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2CLQ_A (3060225) Mitogen-activated protein kinase kinase kinase 5 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.3Å Yes Yes
Ligand-based Druggability Score: 0.25
Ligand-based Druggability Score Percentile: 82%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MAP3K5 is involved in 61 interactions in the network.


Druggability
Overall Druggability Percentile: 93.41
Druggability for Cancer Therapeutics: 96.87
Druggability for Other Therapeutics: 70.84
Cancer-Associated
Cancer-associated percentile : 95.47
Network Articulation Point
Is MAP3K5 critical for communication in the network?


Detailed Graph Legend:Help