Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

S100A13 (Q99584) - Overview - Molecular Target Synopsis

Protein


S100A13, Protein S100-A13
UniProt Q99584

Also Known as S10AD_HUMAN, S100A13

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine. Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1.

2LE9
RAGEC2-S100A13 TETRAMERIC COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for S100A13

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: S100A13 is active in the following subcellular-locations: cytoplasm, secreted.
GO terms: S100A13 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular region, extracellular space, mast cell granule, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project S100A13 has gain in 16 cell-lines, loss in 0 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MALME_3M, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-375, OvCA 432, HEY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HSMM

(see details)

3D Structures


For S100A13 there are:
12 structures (24 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

S100A13 is solved in complex with the approved drug(s):

ANW/AMLEXANOX (2KOT_A, 2KOT_B).

(see details)
Molecular Target 3D Synopsis