Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RIT2 (Q99578) - Overview - Molecular Target Synopsis


RIT2, GTP-binding protein Rit2
UniProt Q99578

Also Known as RIT2_HUMAN, RIT2, RIN, ROC2

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RIT2 is active in the following subcellular-locations: cell membrane, nucleus.
GO terms: RIT2 is active in the following subcellular-locations: cell body, cytoplasm, dendritic tree, membrane raft, neuron projection, nucleus, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RIT2 has gain in 2 cell-lines, loss in 10 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, KM12, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to RIT2 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RIT2 has been screened with compounds ( bioactivities). (see details)