RIT2 (Q99578) - Overview - Molecular Target Synopsis
RIT2, GTP-binding protein Rit2
Also Known as RIT2_HUMAN, RIT2, RIN, ROC2
Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|153||ENSG00000152214||ENST00000282028, ENST00000589109||ENSP00000282028, ENSP00000467217||Q99578-2|
UniProt: RIT2 is active in the following subcellular-locations: cell membrane, nucleus.
GO terms: RIT2 is active in the following subcellular-locations: cell body, cytoplasm, dendritic tree, membrane raft, neuron projection, nucleus, plasma membrane.