Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIT2 (Q99578) - Overview - Molecular Target Synopsis

Protein


RIT2, GTP-binding protein Rit2
UniProt Q99578

Also Known as RIT2_HUMAN, RIT2, RIN, ROC2

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RIT2 is active in the following subcellular-locations: cell membrane, nucleus.
GO terms: RIT2 is active in the following subcellular-locations: cell body, cytoplasm, dendritic tree, membrane raft, neuron projection, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIT2 has gain in 2 cell-lines, loss in 10 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, KM12, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to RIT2 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RIT2 has been screened with compounds ( bioactivities). (see details)