Molecular Target Synopsis
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rpoL (Q980K0) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed5
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria5


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3HKZ_V DNA-directed RNA polymerase subunit L Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 63.3 28.1 Yes No
2 empty 2.59 65.2 12.7 No No
3 empty 2.3 65.8 6.9 No No
4 empty 2.3 61.2 7.2 No No
5 empty 2.13 52.8 6.7 No No
6 empty 2.3 52.4 7.6 No No
7 empty 2.1 60.2 7.7 No No
8 empty 1.78 74.4 5.6 No No
9 empty 1.92 59.6 6.8 No No
10 empty 1.75 72.5 0 No No
3HKZ_L DNA-directed RNA polymerase subunit L Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.38 66.1 32.4 Yes No
2 empty 2.44 61 13.1 No No
3 empty 2.22 79.5 9.3 No No
4 empty 2.18 55.7 9.1 No No
5 empty 1.72 67.9 5.8 No No
6 empty 2.26 62.3 5.2 No No
7 empty 2.14 60.8 5.5 No No
8 empty 2.38 64.4 5.3 No No
9 empty 2.88 55.7 6.6 No No
10 empty 3.07 79.5 0 No No
2PMZ_X DNA-directed RNA polymerase subunit L Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.3 64.5 32.6 Yes No
2 empty 2.5 62.3 9.4 No No
3 empty 2.13 75.6 7.9 No No
4 empty 2.15 56.7 9.2 No No
5 empty 2.15 49.5 7.3 No No
6 empty 2.75 75.7 4.7 No No
7 empty 2.26 56.7 6.6 No No
8 empty 2.24 57.6 5.4 No No
9 empty 1.72 72.4 0 No No
2PMZ_L DNA-directed RNA polymerase subunit L Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.19 60.7 29.2 Yes No
2 empty 2.61 66.6 12.5 No No
3 empty 2.14 79.5 8.3 No No
4 empty 2.26 50.2 11.6 No No
5 empty 2.06 53.1 5.7 No No
6 empty 1.84 64.3 5.9 No No
7 empty 1.74 73.3 6.2 No No
8 empty 2.33 62.2 4.9 No No
2PA8_L DNA-directed RNA polymerase subunit L Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 62.3 34.4 Yes No
2 empty 2.48 67.3 7.3 No No
3 empty 2.71 57.4 7.4 No No
4 empty 2.19 46.6 7 No No
5 empty 1.79 54.8 8.3 No No
6 empty 2.78 58.7 8 No No
7 empty 2.49 69.1 5.4 No No
8 empty 2.9 62.5 7.1 No No
9 empty 2.07 72.6 5.4 No No
10 empty 3.29 70.8 6.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2PA8_L (3170606) DNA-directed RNA polymerase subunit L DCoH-like, RBP11-like subunits of RNA polymerase, UNMATCHED 1.7Å Yes No
2PMZ_L (3170946) DNA-directed RNA polymerase subunit L DCoH-like, RBP11-like subunits of RNA polymerase, UNMATCHED 3.4Å No No
3HKZ_L (3460171) DNA-directed RNA polymerase subunit L DCoH-like, RBP11-like subunits of RNA polymerase, UNMATCHED 3.4Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score