Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

dbh (Q97W02) - Overview - Molecular Target Synopsis

Protein


dbh, DNA polymerase IV
Enzyme Classification 2.7.7.7
UniProt Q97W02

Also Known as DPO4_SACS2, dbh, dpo4

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. Monomer. Interacts with the PCNA heterotrimer via PCNA1.

5EDW
TERNARY STRUCTURE OF DPO4 BOUND TO G IN THE TEMPLATE BASE PAIRED WITH INCOMING DTTP
RCSB/PDB
Inspect Structure
See all 3D Structures for dbh

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
352Q97W02-1

Sub-cellular localization


UniProt: dbh is active in the following subcellular-locations: cytoplasm.
GO terms: dbh is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project dbh has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For dbh there are:
126 structures (175 chains) solved
107 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


dbh has been screened with compounds ( bioactivities). (see details)