Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pezT (Q97QZ1) - Overview - Molecular Target Synopsis

Protein


pezT, Toxin PezT
Enzyme Classification 2.7.1.176
UniProt Q97QZ1

Also Known as PEZT_STRPN, pezT

Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first committed step in cell wall synthesis, which is then blocked. Upon expression in E.coli results in decreased cell growth and viability, followed 3 hours later by growth restoration; the toxic effect and phosphorylation of UNAG are neutralized by coexpression with cognate antitoxin PezA. A mutant lacking the last 11 residues is stably maintained in E.coli, unlike the wild-type which undergoes spontaneous mutation. Expression of the deletion mutant in rapidly growing liquid cultures leads to cell bulging, permeabilization and massive lysis by 1 hour. Cells that survive are not able to undergo cytokinesis. Expression in slowly growing cells leads to bulging but not lysis., Acts as a corepressor of its own operon with PezA; it is not clear if it binds DNA alone. Forms a PezA(2)PezT(2) heterotetramer. The heterotetramer is much more stable than either of the proteins alone, and a specific mechanism may be necessary to liberate the toxin.

2P5T
MOLECULAR AND STRUCTURAL CHARACTERIZATION OF THE PEZAT CHROMOSOMAL TOXIN-ANTITOXIN SYSTEM OF THE HUMAN PATHOGEN STREPTOCOCCUS PNEUMONIAE
RCSB/PDB
Inspect Structure
See all 3D Structures for pezT

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
253Q97QZ1-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pezT has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pezT there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis