Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RUFY1 (Q96T51) - Overview - Molecular Target Synopsis

Protein


RUFY1, RUN and FYVE domain-containing protein 1
UniProt Q96T51

Also Known as RUFY1_HUMAN, RUFY1, RABIP4, ZFYVE12

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding.

2YW8
CRYSTAL STRUCTURE OF HUMAN RUN AND FYVE DOMAIN-CONTAINING PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for RUFY1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RUFY1 is active in the following subcellular-locations: cytoplasm, early endosome membrane.
GO terms: RUFY1 is active in the following subcellular-locations: cytoplasm, cytosol, early endosome membrane, endosome, intracellular membrane-bounded organelle, nuclear speck, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RUFY1 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, EKVX, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M2, SW 900, KPL-4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, MCF-7

(see details)

3D Structures


For RUFY1 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis