Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC49A4 (Q96SL1) - Overview - Molecular Target Synopsis

Protein


SLC49A4, Solute carrier family 49 member 4
UniProt Q96SL1

Also Known as DIRC2_HUMAN, SLC49A4, DIRC2

Electrogenic metabolite transporter.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
478ENSG00000138463ENST00000261038ENSP00000261038Q96SL1-1
411Q96SL1-2
115ENSG00000138463ENST00000477647ENSP00000418554

Sub-cellular localization


UniProt: SLC49A4 is active in the following subcellular-locations: lysosome membrane.
GO terms: SLC49A4 is active in the following subcellular-locations: integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC49A4 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)