Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STRBP (Q96SI9) - Overview - Molecular Target Synopsis

Protein


STRBP, Spermatid perinuclear RNA-binding protein
UniProt Q96SI9

Also Known as STRBP_HUMAN, STRBP, SPNR

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.

2DMY
SOLUTION STRUCTURE OF DSRM DOMAIN IN SPERMATID PERINUCLEAR RNA-BIND PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for STRBP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STRBP is active in the following subcellular-locations: cytoplasm.
GO terms: STRBP is active in the following subcellular-locations: cytoplasm, manchette, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STRBP has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, COLO205, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT, WSU-FSCCL, MHH-PREB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, K562, HeLa-S3

(see details)

3D Structures


For STRBP there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis